AML M6 type is associated with which chromosomal abnormalities?

Acute Myeloid Leukemia, particularly M6 subtype, is typically characterized by specific chromosomal abnormalities. The option noted as the correct answer, which includes del(5q), del(7q), and +8, reflects frequent chromosomal alterations observed in acute myeloid leukemias with myelodysplastic features, including M6.

The deletion of chromosome 5 (del(5q)) is often associated with myelodysplastic syndromes and can lead to ineffective hematopoiesis and chronic cytopenias, which align with the clinical picture of M6. Similarly, del(7q) has been implicated in various subtypes of AML and is indicative of a poorer prognosis. The presence of an extra copy of chromosome 8 (+8) is also frequently noted in hematological malignancies and can contribute to the aggressiveness of the leukemia.

In contrast, the other options represent translocations or other abnormalities that are more characteristic of different subtypes of leukemia. For instance, t(15;17)(q22;q11-12) is mainly associated with acute promyelocytic leukemia (APL), while t(9;11)(p22;q23) is more commonly linked to acute monocytic leukemia.