In the context of prenatal testing, low levels of which analyte would likely indicate a risk of trisomy?

In the context of prenatal testing, low levels of Alpha-Fetoprotein (AFP) are associated with an increased risk for trisomy, particularly trisomy 21 (Down syndrome). AFP is a protein produced by the fetal liver, and its levels can be measured through maternal serum screening. In pregnancies affected by trisomy 21, the AFP levels tend to be lower than expected.

Low AFP levels are part of a combination of markers that are assessed during first and second trimester screenings. This screening helps to evaluate the risk of certain chromosomal abnormalities and can lead to further diagnostic testing if necessary. A comprehensive understanding of these biomarkers and their implications is vital in prenatal care for identifying potential risks to the fetus.