What is the minimum band level needed to detect Prader-Willi syndrome?

To detect Prader-Willi syndrome, the minimum band level needed is typically around 550. This level of resolution allows for the identification of deletions or uniparental disomy on chromosome 15, which are the main genetic abnormalities associated with Prader-Willi syndrome.

The clarity of the banding pattern at 550 should be sufficient to visualize these important genetic features that are indicative of the syndrome. Higher banding levels (like 600 or 700) may provide even better resolution, but they are not strictly necessary for the initial detection of the specific abnormalities related to Prader-Willi syndrome. Therefore, achieving a resolution of 550 is generally recognized as the threshold necessary for effective screening in clinical cytogenetics for this condition.