What is the suggested level for most constitutional specimens according to CAP regulations?

The suggested level for most constitutional specimens according to CAP (College of American Pathologists) regulations is 550. This recommendation is based on the need for sufficient resolution during microscopic examination to accurately detect chromosomal abnormalities. A level of 550 provides an optimal balance between adequate chromosome visibility and the practicality of preparing and analyzing specimens.

Constitutional specimens, often derived from blood or tissue, are crucial for genetics diagnostics because they reflect the standard chromosomal makeup of the individual. Adhering to this suggested level ensures that the samples are properly characterized and that any potential abnormalities can be reliably identified and interpreted. Higher levels may allow for more detailed analysis, but 550 strikes a necessary compromise for standard practice, ensuring diagnostic quality while remaining manageable.