What specific genetic rearrangement is associated with AML M2 type?

The genetic rearrangement specifically associated with Acute Myeloid Leukemia (AML) M2 is the translocation t(8;21)(q22;q22). This particular rearrangement results in the fusion of the RUNX1 gene, located on chromosome 21, with the AML1 gene, located on chromosome 8. This fusion gene plays a critical role in the pathogenesis of AML M2, as it alters normal hematopoiesis and contributes to the leukemogenic process.

In cases of AML M2, the presence of this t(8;21) translocation can often be detected through cytogenetic analysis and is a defining characteristic that helps in the diagnosis and classification of the disease. It is also associated with a relatively favorable prognosis when compared to other types of AML with different genetic aberrations. Understanding the significance of this translocation is crucial for both the diagnosis and treatment planning in patients with AML M2.

The other options represent genetic rearrangements associated with different subtypes of Acute Myeloid Leukemia or other hematological malignancies, hence their relevance to AML M2 specifically.