Which AML type is associated with the genetic change inv(16)(p13q22)?

The genetic change inv(16)(p13q22) is specifically associated with Acute Myeloid Leukemia (AML) M4, which is classified as acute myelomonocytic leukemia. This chromosomal inversion leads to the formation of a fusion gene, which is often implicated in the pathology of this specific type of leukemia. The presence of inv(16) typically suggests the involvement of certain myeloid cells, particularly those that are immature monocytes and granulocytes, characteristic of AML M4.

In patients with this genetic alteration, there is a distinct clinical and cytogenetic profile associated with AML M4, including features such as a specific morphology and immunophenotype, which further supports the connection between the genetic change and this type of leukemia. Other types of AML, such as M5, M6, and M7, are associated with different cytogenetic abnormalities and phenotypic characteristics that do not include inv(16). Therefore, recognizing the association between inv(16) and AML M4 is crucial for accurate diagnosis and treatment decisions in hematological malignancies.