Which genetic change is often found in AML M5 type?

Acute Myeloid Leukemia (AML) M5 is characterized by monocytic differentiation and is known to be associated with specific genetic abnormalities. One of the most significant changes that is frequently observed in AML M5 is the translocation t(9;11)(p22;q23). This genetic alteration involves the MLL (KMT2A) gene located on chromosome 11, which is crucial for normal hematopoiesis.

This translocation leads to the formation of fusion genes that disrupt normal gene regulation and promote leukemogenesis. In the context of AML M5, the presence of t(9;11) is indicative of a more aggressive disease and can have implications for treatment strategies and prognosis.

The other options represent genetic changes associated with different subtypes of acute myeloid leukemia or other conditions. For instance, del(5q) is commonly associated with myelodysplastic syndromes rather than AML M5. The translocation t(15;17)(q22;q11-12) is a hallmark of acute promyelocytic leukemia (APL), while t(8;21)(q22;q22) is often seen in AML M2. Understanding these associations is crucial in the diagnosis and differentiation of