Which of the following is an advantage of FISH diagnostics concerning interphase testing?

FISH (Fluorescence In Situ Hybridization) offers several advantages in diagnostics, especially in the context of interphase testing. One notable benefit is that it requires only simple microscope analysis. This allows for the direct visualization of fluorescent signals from hybridized probes, providing a clear and efficient means of assessing chromosomal abnormalities in non-dividing cells, such as those found in interphase.

Using FISH in interphase cells avoids the need for extensive culture processes that can be time-consuming and may introduce artifacts. Moreover, the ease of analysis with a standard fluorescence microscope makes FISH accessible for many laboratory settings, enabling faster and more reliable results compared to other methods that may require complex preparations or advanced technologies.

In contrast, FISH does not solely detect mutations, as it can identify deletions, amplifications, and translocations. While some advanced equipment may enhance the capabilities of FISH analysis, the fundamental requirement is simply a fluorescence microscope, underscoring the practicality of this diagnostic technique.