Which tissue has the best success rate and ability to detect abnormalities in spontaneous abortion cases?

Chorionic villi are the most effective tissue for detecting genetic abnormalities in cases of spontaneous abortion due to their unique characteristics. Chorionic villi are finger-like projections from the placental tissue that contain cells derived from both maternal and fetal sources. These cells undergo rapid growth and can be analyzed while retaining the genetic information from the embryo.

When evaluating cases of spontaneous abortion, chorionic villi can provide a robust sample for cytogenetic analysis, allowing for high-resolution karyotyping and molecular studies to identify chromosomal abnormalities such as aneuploidies or structural rearrangements. The early development of chorionic villi means that they can often be obtained in sufficient quantity and quality, which enhances the likelihood of successful diagnosis.

In contrast, placental tissue, while useful, may be less accessible and not always as representative of the fetal genetic material. Amniotic fluid can also provide genetic information but typically requires a viable pregnancy beyond the first trimester for collection, which doesn’t apply in spontaneous abortion cases. Fibroblast cultures are generally conducted on postnatal tissues, which are not relevant for immediate analysis following a miscarriage.

Therefore, the choice of chorionic villi demonstrates an understanding of the timing and nature of tissue sampling in relation to the detection