Which type of AML is characterized by the absence of differentiation and associated chromosome changes?

The correct answer identifies AML M1 as the type of acute myeloid leukemia characterized by the absence of differentiation. This variant, also known as acute myeloblastic leukemia without maturation, typically shows a predominance of myeloblasts that do not develop into more mature forms of myeloid cells. This lack of differentiation reflects the immature state of these cells and contributes to the aggressive nature of the disease.

Additionally, AML M1 is often associated with specific chromosome changes such as translocations or other cytogenetic abnormalities. These genetic alterations can play a significant role in both the prognosis and treatment of the condition.

In contrast, other types of AML, such as AML M2, M3, and M4, are characterized by varying degrees of myeloid differentiation. For instance, AML M2 shows evidence of maturation, while AML M3, also known as promyelocytic leukemia, is associated with characteristic promyelocytes and specific chromosomal translocations. AML M4 involves a mix of myeloid and monocytic cells, which further differentiates it from AML M1.

Understanding the characteristics of AML M1, including its lack of differentiation and associated cytogenetic changes, is crucial for developing appropriate treatment strategies and anticipating the